Prevalence of Metallo-β-lactamases in Imipenem-non-susceptiblePseudomonas aeruginosaandAcinetobacter baumannii

Prevalence of Metallo-β-lactamases in Imipenem-non- susceptible Pseudomonas aeruginosa and Acinetobacter baumannii

Background: Metallo-β-lactamases (MBLs) have been reported in gram negative bacilli and are becoming increasingly important clinically because the enzymes hydrolyse almost all β-lactams, including carbapenems. Thus, the present study was conducted to determine the prevalence of MBL types in imipenem-nonsusceptible Pseudomonas aeruginosa and Acinetobacter baumannii isolated from a tertiary teach...

Antimicrobial Effect of Imipenem-Functionalized Fe2O3 Nanoparticles on Pseudomonas aeruginosa Producing Metallo β-lactamases

Background: Resistant strains of Pseudomonas aeruginosa to imipenem was medical treatment problem, especially in burnt units of hospitals. Objectives: This study was conducted to evaluate the antimicrobial effect of Fe2O3 nanoparticles alone and functionalized with imipenem on P. aeruginosa starins producing metallo b-lactamases (MBL). Materials and Methods: A disk diffusion method was used to...

Metallo-β-Lactamases and Aptamer-Based Inhibition

An evolution of antibiotic-resistant bacteria has resulted in the need for new antibiotics. β-Lactam based drugs are the most predominantly prescribed antibiotics to combat bacterial infections; however, production of β-lactamases, which catalyze the hydrolysis of the β-lactam bond of this class of antibiotics, by pathogenic bacteria such as Bacillus cereus, are rendering them useless. Some inh...

Phenotypic and Genotypic Detection of Metallo-Beta-Lactamases in Carbapenem Resistant Acinetobacter baumannii

antimicrobial effect of imipenem-functionalized fe2o3 nanoparticles on pseudomonas aeruginosa producing metallo β-lactamases

background: resistant strains of pseudomonas aeruginosa to imipenem was medical treatment problem, especiallyin burnt units of hospitals. objectives: this study was conducted to evaluate the antimicrobial effect of fe2o3 nanoparticles alone and functionalized with imipenem on p. aeruginosa starins producing metallo b-lactamases (mbl).materials and methods: a disk diffusion method was used to is...